Role of Ethanolic Extract of Microdus brasiliensis (Duby) Ther. in Protecting Survival Rate in Sepsis: An In vivo Study

The present study investigated the phytochemical, total flavonoid and phenolic content, antibacterial activity, acute toxicity studies, hemodynamic parameters, myeloperoxidase activity of ethanolic extract Microdus brasiliensis its effects on cecal ligation puncture induced sepsis in mice. preliminary phytochemical screening showed that contains alkaloids, terpenoids, flavonoids, phenolics, saponins tannins. found to contain good amounts content. At equivalent concentration, activities as potent streptomycin against Staphylococcus aureus, Salmonella typhi Escherichia coli. Acute studies mice out was non-toxic up 2000 mg/kg body weight. both low high doses, improved parameters such mean arterial pressure decreased optical density blood serum activity. Moreover, at a dose, reduced survival rate 80.34±3.67 % might be through pro-inflammatory effects. results indicate can favorable natural source for treatment